Obesity
Obesity is an epidemic in America, with 64% of adults overweight and 26% obese. This is especially apparent in the Chandler home, in which most of it's residents are fucking fat. Chris, Barbara and even their cat, Desi.
Chris seems to be in denial of his own obesity, despite the fact that he has been overweight since childhood. This is evidenced by the fact that he portrays himself as a slim, barrel chested hero in his comics and in Christian Weston Chandler's FUTURE MESSAGE when he describes himself as "fit as a fiddle".
Another example of this was when he created a character for his comics named Sammy, whom Chris stated is based off of him when he "temporary gained weight, Became stupid, and went to watch television at ghost command", even though he has always been this way.