Laura Beth Dorazio
Laura Beth Dorazio was Chris's first major crush in high school.
She was a cheerleader, and befriended Chris. When she asked if Chris was crushing on anyone, he nonchalantly told her that he had a crush on her. After telling him that she'd think about it for a couple of weeks, she told Chris that she liked him as a friend, and only that. That was essentially the end of their relationship. However, Chris considered her significant to be mentioned in his comic. Chris also added her to his Facebook.
Comic appearances
Laura is mentioned in Sonichu #7 where Chris describes her as "so fine".
Other
Laura is depicted as a character in Chris's Mario Kart 64 Lego Raceway videos as racer #16.
It's also likely that Laura is the "MHS Cheerleader" character mod he made in ModNation Racers